2,5-Dimethyl-3-(3-methylthiophen-2-yl)perhydropyrrolo[3,4-d]isoxazole-4,6-dione
نویسندگان
چکیده
The crystal structure of the title compound, C(12)H(14)N(2)O(3)S, exhibits intra-molecular C-H⋯S and inter-molecular C-H⋯S, C-H⋯O hydrogen bonds, C-S⋯N [S⋯N = 2.980 (2) Å, C-S⋯N = 145.78 (17)°] and C-H⋯π inter-actions; these inter-actions generate two C(5) chains and S(4), S(6) and R(4) (4)(28) ring motifs. The isoxazole ring has an envelope conformation; the N atom, which is the flap atom, is displaced by 0.261 (2) Å from the plane defined by the remaining four atoms. The dihedral angle between the succinimide and thio-phene rings is 46.8 (2)°.
منابع مشابه
Regioselectivity of 1,3-dipolar cycloadditions and antimicrobial activity of isoxazoline, pyrrolo[3,4-d]isoxazole-4,6-diones, pyrazolo[3,4-d]pyridazines and pyrazolo[1,5-a]pyrimidines.
BACKGROUND Isoxazoles exhibit interesting biological activities, and the 1,3-dipolar cycloaddition(13DC) reactions play an important role in both mechanistic and synthetic organic chemistry. Pyrazoles and annulated pyrazoles exhibit some diverse biological activities. They are used as antipyretic, analgesic drugs, tranquilizing, and herbicidal agents. Pyrazoles are also used extensively as usef...
متن کامل(3R,3aS,6aR)-2,5-Dimethyl-3-(5-phenyl-2-thienyl)perhydropyrrolo[3,4-d][1,2]oxazole-4,6-dione
The crystal structure of the title compound, C(17)H(16)N(2)O(3)S, exhibits intra-molecular C-H⋯S and inter-molecular C-H⋯S and C-H⋯O hydrogen bonds, C-S⋯N [S⋯N = 3.033 (2) Å and C-S⋯N = 142.76 (9)°] inter-actions, and C-H⋯π inter-actions; these inter-actions generate S(4), S(6) and R(2) (2)(14) ring motifs. The isoxazole ring adopts an envelope conformation, with the N atom displaced by 0.672 (...
متن کاملC,O-dialkylation of Meldrum's acid: synthesis and reactivity of 1,3,7,7-tetramethyl-4H,10H-6,8,9-trioxa-2-thiabenz[f]azulen-5-one.
Reaction of Meldrum's acid with 3,4-bis(chloromethyl)-2,5-dimethylthiophene (1) or 3,4-bis(bromomethyl)-2,5-dimethylthiophene (2) produces the kinetically favored C,O-dialkylation product, 1,3,7,7-tetramethyl-4H,10H-6,8,9-trioxa-2-thiabenz[f]azulen-5-one (4). Recrystallization of 4 from refluxing methanol results in the methanolysis product 5-(4-methoxymethyl-2,5-dimethylthiophen-3-ylmethyl)-2,...
متن کامل3-(6-Benzyloxy-2,2-dimethylperhydrofuro[2,3-d][1,3]dioxol-5-yl)-5-(4-bromophenyl)-2-phenylperhydropyrrolo[3,4-d]isoxazole-4,6-dione
In the title compound, C(31)H(29)BrN(2)O(7), the isoxazolidine ring adopts a twist conformation, while the tetrahydrofuran, dioxolone and pyrrole rings adopt envelope conformations. The structure is stabilized by inter-molecular C-H⋯O hydrogen bonds and C-H⋯π inter-actions.
متن کاملCrystalline conjugated polymer containing fused 2,5-di(thiophen-2-yl)thieno[2,3-b]thiophene and thieno[3,4-c]pyrrole-4,6-dione units for bulk heterojunction solar cells.
A new conjugated polymer, PDTTTPD, comprising 2,5-di(thiophen-2-yl)thieno[3,2-b]thiophene and thieno[3,4-c]pyrrole-4,6-dione units, exhibits high crystallinity and excellent thermal stability. A device incorporating PDTTTPD and [6,6]-phenyl-C(71)-butyric acid methyl ester (1:1, w/w) exhibited a power conversion efficiency of 5.1%.
متن کامل